Colloidal nanoparticles in biotechnology by Abdelhamid Elaissari

By Abdelhamid Elaissari

Dr. Abdelhamid Elaissari, the world over revered writer and researcher, reviews on and analyzes a wide diversity of vital findings from new reports at the use of colloidal nanoparticles in biomedical, nutrients, and environmental diagnostics and analyses. in the course of the presentation, the booklet makes use of a mix of classical instruments, together with optical microscopy, atomic strength microscopy, microsystems, and microfluidics, that can assist you take complete good thing about colloidal nanoparticles on your personal examine and purposes.

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45. Janssen EAWG, van Herk AM, German AL. Encapsulation of inorganic filler particles by emulsion polymerization. ACS Div Polym Chem Polym Prep 1993;34:532–533. 46. Bourgeat-Lami E. Hollow particles: synthetic pathways and potential applications. In: Ela€ıssari A, editor. Colloidal Polymers. Surfactant Science Series, 115. New York: Marcel Dekker; 2003. pp. 189–223. 47. Vitry S, Mezzino A, Gauthier C, Cavaille J-Y, Lefebvre F, Bourgeat-Lami E. Hybrid copolymer latexes cross-linked with methacryloxy propyl trimethoxy silane.

This copolymer system is believed to have the potential for drug-delivery applications because of the biocompatibility of PMAA and PDEA. 3), which can be protonated at low pH and makes the block hydrophilic. Because both blocks have different pKa values and different chain lengths, the hydrophile–lipophile balance (HLB) values of the block copolymer at high or low pH values are different. Armes et al. reported on the reversible formation of block copolymer micelles using either methoxy-capped poly(ethylene glycol) (MePEO) or poly[2-(dimethylamino)ethyl methacrylate] (PDMA) as the hydrophilic block, combined with PDEA, poly(2-(diisopropylamino)ethyl methacrylate) (PDPAEMA or PDPA), or poly[(2-(N-morpholino)ethyl methacrylate] (PMEMA) as the hydrophobic block.

From the point view of the structure, multicompartment micelles have water-soluble shells for stabilizing nanoparticles, and multicompartment hydrophobic cores for accommodating two or more incompatible drugs simultaneously (24–27). In order to obtain the multicompartment micelles, our group designed and synthesized a kind of hyperbranched star-block copolymer (HP-star-PDMAEMA-b-POFPMA) via oxyanion-initiated polymerization process, using hydroxyl-terminated hyperbranched poly[3-ethyl-3-(hydroxylmethyl)oxetane] (HP) as a macroinitiator precursor with multireactive sites, as shown in Fig.

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