Biotechnology in China I: From Bioreaction to Bioseparation by Hui-Lei Yu, Jian-He Xu, Wen-Ya Lu, Guo-Qiang Lin (auth.),

By Hui-Lei Yu, Jian-He Xu, Wen-Ya Lu, Guo-Qiang Lin (auth.), Jian-Jiang Zhong, Feng-Wu Bai, Wei Zhang (eds.)

In fresh years, biotechnology examine and improvement (R&D) in China has been receiving expanding cognizance from the realm. With the open-door coverage of the chinese language govt, many foreign guides (for academia) and massive industry power (for undefined) represent the 2 titanic purposes for the above phen- enon. Biotechnology has develop into one of many priorities in Mainland China for therefore- ing many very important difficulties, equivalent to nutrition offer, future health care, setting safety, or even strength. The significant govt has been enforcing a c- ple of courses which conceal a large spectrum in uncomplicated examine, high-tech devel- ment and industrialization, resembling simple study application (973 Plan), Hi-Tech R&D application (863 Plan), Key technology & know-how challenge fixing software (Gong-guan Plan), in addition to the institution of facilities of excellence - Key Laboratories and Engineering facilities, and so forth. The investment from a number of neighborhood gove- ments and for R&D has additionally been expanding consistently. Biotechnology facilities in Shenzhen, Shanghai and Beijing were validated. There are greater than four hundred universities, study institutes and firms and a complete of over 20,000 researchers enthusiastic about biotechnology within the Mainland. The variety of learn papers released the world over and patent functions is additionally expanding speedily. furthermore, the massive industry capability with approximately 1. four billion inhabitants, that is already open to the skin international, has supplied quite a few possibilities for int- nationwide and family businesses to speculate in biotechnology, which pushes ahead the biotechnology industrialization in China.

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Extra resources for Biotechnology in China I: From Bioreaction to Bioseparation and Bioremediation

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2) [68]. 3 Amidase Amidase, amide bond-cleaving enzymes, exists ubiquitously in nature in both prokaryotic and eukaryotic forms. To the best of our knowledge, amidase-mediated processes have been extensively investigated, especially, the hydrolysis of amides to the corresponding carboxylic acid and ammonia. Additionally, hydroxamic acids were formed owing to the acyl transfer activity of amidase in the presence of hydroxylamine. Two reactions involved are shown in Scheme 2. Besides, amidase is also capable of catalyzing diverse reactions such as ester hydrolysis, hydroxamic acid hydrolysis, acid hydrazide hydrolysis, amide transfer on hydrazine, ester transfer on hydroxylamine, ester transfer on hydrazine and so on [69].

20 Deracemization of a-phenyl- and r-substituted a-phenoxypropanoic acids by enzymes of Nocardia diaphanozonaria JCM3208 (cited from [214–216]) convert one diastereomer selectively to another diastereomer. Both enzymes are useful in the deracemization process, offering a potential of 100% yield [209, 210]. Faber’s group has employed a few racemases for obtaining high yield in dynamic kinetic resolution or in auxiliary biocatalytic recycling processes. Faber and coworkers employed a mandelate racemase whose broad substrate tolerance for b,gunsaturated a-hydroxycarboxylic acids makes it a good candidate [211].

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