Biotechnology Annual Review, Vol. 1 by M. Raafat El-Gewely

By M. Raafat El-Gewely

The Biotechnology Annual assessment covers some of the advancements in biotechnology within the type of finished, illustrated and good referenced reports. With the growth of the sector of biotechnology, coupled with the mammoth elevate within the variety of new journals reporting fresh ends up in this box, the necessity for a booklet that's consistently supplying reports is pressing. consequently, each one quantity of the Biotechnology Annual evaluate could have a couple of studies masking assorted points of biotechnology. Reviewed themes will comprise biotechnology purposes in medication, agriculture, marine biology, undefined, bioremedation and the surroundings. basic difficulties facing bettering the technical wisdom encountering biotechnology usage whatever the box of program should be rather emphasised. This sequence might help either scholars and academics, researchers in addition to directors to stay an expert on all suitable concerns in biotechnology.

Proposals for contributions and/or feedback for issues for destiny volumes during this sequence might be despatched to the Editor: professor M.R. El-Gewely division of Biotechnology college of Tromslø IMB, MH-Bygget N-9037 Tromsø Norway Tel: (+47) seventy seven 644000 Fax: (+47) seventy seven 645350

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Fig. 25. The identification of human proteins by gel chromatographic separation (above) and by the color test (below). 0 Ciba-Geigy. 33 Fig. 26. Harvesting cells by centrifugation. The centrifuge effluent is piped out to the automatic waste water treatment system for heat sterilization (see Fig. 24). 0 F. , Basel [20]. Fig. 27. Inactivated, centrifugally separated and deep-frozen cell mass with genetically engineered interferon after completion of a fermentation process in the Roche Biotechnology Pilot Plant.

However, the molecular nature of the majority of these listed diseases is unknown [163]. On the positive side, the techniques for gene therapy have improved tremendously in recent years. Consequently, gene therapy appears to be gaining momentum as a powerful tool for the therapy of genetic diseases and cancer in the near future and it will remain a subject of scientific and clinical research. Somatic gene therapy, in contrast to germline therapy, is the subject of the current research in gene therapy for human diseases.

Since many mutations in humans are caused by nonsense mutations, gene therapy by suppressor tRNAs has been suggested [165]. Germline gene therapy has been demonstrated in transgenic mice, for example, using a full-length and truncated form of the dystrophin cDNA [161]. Some of the genetic diseases that are candidates for somatic gene therapy are listed in Table 2. Modes of gene therapy Basically, there are two general methods for the administration of genetic gene therapy, ex vivo and in vivo [ 1641.

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