Biomedical nanomaterials by Yuliang Zhao, Youqing Shen

By Yuliang Zhao, Youqing Shen

The publication discusses in a close demeanour quite a few nanomaterials used for biomedical functions, together with scientific functions, analysis and tissue engineering. After the presentation of an summary of biomedical nanomaterials, together with their class and functions, the 1st a part of the booklet is dedicated to biomedical nanomaterials for remedy purposes. for instance, polymer micelles, dendrimers, Read more...

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The ebook discusses in a close demeanour quite a few nanomaterials used for biomedical purposes, together with medical functions, analysis and tissue engineering. Read more...

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Surface coating. PEGylation is effective in improving systemic circulation of NMs. For example, the blood clearance rate (CL) and mean resident time (MRT) of Dox [121] and curcumin [122] in the nanoformulations were greatly extended with PEGylation. Surfactant coating was also effective in adjusting the surface characteristics of NMs, and thus changed blood PK of the drugs [129]. 5. Ligand modification. Generally, ligand modification promotes preferential uptake by the target organ. In order to increase the targeting efficiency for indomethacin delivery, PAMAMs modified with different amounts of folic acid were investigated.

9). 11) [106]. 9 Changes of C max and T max in different compartments with different K rel and K res . 6 Kres (h−1) dox in the tumor site, respectively; T int lipo , T ecs dox , and T tu dox , the time at which C max was reached. 10 Simulations of the time courses of free and liposomal DOX in mice bearing P388 tumor in the peritoneal cavity [106]. 6 (h−1 ), and (d) krel = 6 (h−1 ). 11 Effect of krel on the antitumor effect of liposomal DOX [106]. ) 19 1 Pharmacokinetics and Pharmacodynamics (PK/PD) of Bionanomaterials The model is useful, especially in predicting how drugs release and the nonspecific distribution affects the delivery efficiency of the encapsulated drugs.

1% w/v PAMAM Peg5k-dendritic lysine-cholic acid (PEG5k-CA8) + paclitaxel Peg5k-dendritic lysine-cholic acid (PEG5k-CA8) + daunorubicin; nontargeted dendrimer CLL1-Peg5k-dendritic lysine-cholic acid (PEG5k-CA8) + daunorubicin; targeted dendrimer, 14 nm Peg5k-dendritic lysine-cholic acid (PEG5k-CA8) + daunorubicin; nontargeted dendrimer CLL1-Peg5k-dendritic lysine-cholic acid (PEG5k-CA8) + daunorubicin; targeted dendrimer, 14 nm Description Pulmonary absorption, rats. 4-fold) Pulmonary absorption, rats.

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