By Andrei G. Pakhomov, Damijan Miklavcic, Marko S. Markov
"A mirrored image of the serious learn of the results of electromagnetic fields on dwelling tissues that has taken position over the past a number of many years, this publication discusses the theoretical and experimental proof and issues the results of sturdy electromagnetic fields and/or electrical pulses and their value in drugs and biology. The authors current the fundamental suggestions utilized in electroporation and the complicated equipment for construction of nanopores, highlighting their easy technological know-how and medical purposes. themes contain nano electroporation, vintage electroporaiton, experimental facts for electroporation of residing cells, and electroporation for melanoma and wound healing"--Provided by way of writer. learn more... content material: fundamentals of Electroporation actual Chemical thought of Membrane Electroporation and Electrotransfer of Biogenic brokers, E. Neumann and S. Kakorin Bioelectric influence of extreme Nanosecond Pulses, K.H. Schoenbach caused Transmembrane Voltage-Theory, Modeling, and Experiments, T. Kotnik and G. Pucihar Electroporation: A evaluation of uncomplicated difficulties in conception and scan, M.S. Markov Mechanisms of Electroporation in Lipid structures Electrodeformation, Electroporation, and Electrofusion of Cell-Sized Lipid Vesicles, R. Dimova Fluorescent tools in review of Nanopore Conductivity and Their Computational Validation, M. Kotulska, W. Dyrka, and P. Sadowski Electroporation of Lipid Membranes: Insights from Molecular Dynamics Simulations, M. Tarek and L. Delemotte Nanoscale Restructuring of Lipid Bilayers in Nanosecond electrical Fields, P.T. Vernier Mechanisms of Electroporation of Cells Nanopores: a different Transmembrane Passageway in Electroporated Cells, A.G. Pakhomov and O.N. Pakhomova version of cellphone Membrane Electroporation and Transmembrane Molecular shipping, D. Miklavcic and L. Towhidi Kinetics of Pore Formation and Disappearance within the cellphone in the course of Electroporation, G. Saulis the heartbeat Intensity-Duration Dependency for telephone Membrane Electroporation, D. Miklavcic, G. Pucihar, A.M. Lebar, J. Krmelj, and L. Towhidi Mechanisms of Electroporation in Tissues Drug-Free, stable Tumor Ablation via Electroporating Pulses: Mechanisms That Couple to Necrotic and Apoptotic mobilephone demise Pathways, A.T. Esser, K.C. Smith, T.R. Gowrishankar, and J.C. Weaver Gene Electrotransfer: From simple strategies to Preclinical functions, J.-M. Escoffre, A. Paganin-Gioanni, E. Bellard, M. Golzio, M.-P. Rols, and J. Teissie Technical issues Modeling electrical box Distribution In Vivo, N. Pavselj, A. Zupanic, and D. Miklavcic innovations of Electroporation Pulse iteration and assessment of electrical Pulse turbines for mobilephone and Tissue Electroporation, M. Rebersek and D. Miklavcic new release of Ultrashort Pulses, J.F. Kolb Nanosecond Pulsed electrical box supply to organic Samples: problems and strength suggestions, A. Silve, J. Villemejane, V. Joubert, A. Ivorra, and L.M. Mir functions of Electroporation Translation of Electroporation-Mediated DNA supply to the health center, L.C. Heller and R. Heller scientific Electrochemotherapy: The Italian event, C.R. Rossi and L.G. Campana Tumor Blood Flow-Modifying results of Electroporation and Electrochemotherapy-Experimental proof and Implications for the remedy, T. Jarm, M. Cemazar, and G. Sersa lectrochemotherapy as a part of an Immunotherapy approach within the therapy of melanoma, J. Gehl ombined electric box and Ultrasound: A Nondrug-Based approach for Tumor Ablation, P.F. Forde, C. Twomey, G.C. O' Sullivan, and D. M. Soden mixed Modality treatment: Electrochemotherapy with Tumor Irradiation, G. Sersa, S. Kranjc, and M. Cemazar Irreversible Electroporation in drugs, B. Rubinsky meals and Biomaterials Processing Assisted via Electroporation, N. Lebovka and E. Vorobiev In Vivo Electroporation: a massive damage Mechanism in electric surprise Trauma, I. Barakat, J. Gallaher, H. Chen, and R.C. Lee Index summary: Reflecting the serious research of the consequences of electromagnetic fields on dwelling tissues that has taken position through the years, this name summarizes the experimental findings and theories regarding permeabilization of biomembranes by way of pulsed electrical fields. it's meant generally for biomedical and actual scientists, engineers, and clinicians. learn more...
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Additional info for Advanced electroporation techniques in biology and medicine
2004). It is able to permeate the plasma membrane, nuclear membrane, and other organelle membranes of living cells and interacts with DNA and RNA by intercalation or electrostatic attraction, respectively. Experiments with HL-60 cells, where 10 ns pulses of 65 kV/cm field amplitude were applied, showed an exponential decrease in the average fluorescence intensity in the nucleus with a time constant of approximately 3 min. These results showed that nanosecond pulses cause an increase in the permeability of the nuclear membrane, with a subsequent outflow of labeled DNA.
From Nuccitelli, R. , Int. J. Cancer, 125, 438, 2009. , the mitochondrial membranes. , 2002) and/or mitochondrial membrane voltage-dependent anion channels (Savill and Haslett, 1995; Tsujimot and Shimizu, 2002). Weaver’s hypothesis is that ultrashort pulses change the transmembrane voltage at mitochondrial membrane sites, which leads to an opening of the MPTP, inducing apoptosis (Weaver, 2003). , 2006). There is evidence that nsPEF stimulation with multiple, intense pulses causes damage to DNA or other critical proteins.
1972, Permeability changes induced by electrical impulses in vesicular membranes, J. Membr. , 10, 279–290. , 2009, Intracellular DNA damage induced by non-thermal, intense narrowband electric fields, IEEE Trans. Dielect. Electr. , 16, 1288–1293. , 2006, Nanosecond pulsed electric fields cause melanomas to self-destruct, Biochem. Biophys. Res. , 343, 351–360. , Ren, W. , 2009, A new pulsed electric field therapy for melanoma disrupts the tumor’s blood supply and causes complete remission without recurrence, Int.